Yes, this is possible. But if they are in two different parts of the country, then in MBG 6.0 you will need to make use of the Zones. Zones are helpful, so that phones in New York will have that MBG as it primary and the fail back to Houston only when NY is not available.
Without Zones, the Teleworker sets are shared based on what load balancing you have set within the cluster.
Hope this info helps.