We had a 3300 2x 30 trunk to an Alcatel 4400 and we used QSIG.
Unfortunately, that was a transition setup and it is now long gone.
QSIG requires you configure each end to be Master or Slave; you need to decide which side provides the clocking, you need to select QSIG BC at both ends (unless you need to use GF), and after that it's just call routing.